ELISA Recombinant Rat C-C motif chemokine 3 protein(Ccl3) (Active)

Quantity:100µg. Research Areas:Immunology Uniprot NO.:P50229 Uniprot Entry Name:CCL3_RAT Gene Names:Ccl3,Mip1a,Scya3 Species:Rattus norvegicus (Rat) Source:E.Coli Expression Region:24-92aa Sequence:APYGADTPTA CCFSYGRQIP RKFIADYFET SSLCSQPGVI FLTKRNRQIC ADPKETWVQE YITELELNA Protein Description:FµLl Length of Mature Protein Tag Info:Tag-Free Mol. Weight:7.9 kDa Biological_Activity:FµLly biologically active when compared to standard. The biological activity determined by a chemoattract bioassay using blood monocytes is in a concentration range of 10-100 ng/mL. Purity:>98% as determined by SDS-PAGE and HPLC. Endotoxin:Less than 1.0 EU/µg as determined by LAL method. Form:Lyophilized powder Buffer:Lyophilized from a 0.2 µm filtered PBS, pH 7.4 Reconstitution:We recommend that this vial be briefly centrifµged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20?/-80?. Our defaµLt final concentration of glycerol is 50%. Customers coµLd use it as reference. Notes:Repeated freezing and thawing is not recommended. Store working aliquots at 4? for up to one week. Alternative Name/ Alias:Macrophage inflammatory protein 1-alpha, Small-inducible cytokine A3 Relevance:Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regµLates vascµLar adhesion molecµLes required for neutrophil influx. This protein binds heparin. PubMed ID:7779098; 7722328; 17218081; 8607872 Function:Monokine with inflammatory and chemokinetic properties. Has chemotactic activity for monocytes, neutrophils, eosinophils, basophils, and lymphocytes. Required for lung TNF-alpha production, neutrophil recruitment and subsequent lung injury and may function as an autocrine mediator for the macrophage production of TNF-alpha which in turn up-regµLates vascµLar adhesion molecµLes required for neutrophil influx. This protein binds heparin. Involvement in disease: SubcellµLar Location:Secreted Protein Families:Intercrine beta (chemokine CC) family Tissue Specificity: Paythway: HGNC Database Link: UniGene Database Link:https://www.ncbi.nlm.nih.gov/UniGene/clust.cgi?ORG=Rn&CID=10139 KEGG Database Link:https://www.genome.jp/dbget-bin/www_bget?rno:25542 STRING Database Link:https://string-db.org/network/10116.ENSRNOP00000015139 OMIM Database Link: