ELISA PRKAB1 Monoclonal anti-

Quantity :100µL Clone Number: Aliases:1300015D22Rik; 5 AMP activated protein kinase subunit beta 1; 5-AMP-activated protein kinase subunit beta-1; AAKB1_; AMP-ACTIVATED PROTEIN KINASE, NONCATALYTIC, BETA-1; AMP-activated, noncatalytic, beta-1; AMPK; AMPK beta 1 chain; Product Type:Monoclonal Antibody Immunogen Species: UniProt ID:Q9Y478 Immunogen:Purified recombinant AMPK beta 1 protein fragments expressed in E.coli. Raised in:Mouse Reactivity:,Mouse,Rat,Monkey Tested Applications:ELISA,WB,IHC,ICC,IP;Recommended dilution:WB:1:500-1:5000,IHC:1:50-1:500,ICC:1:50-1:200,IP:1:200-1:2000 Background:Non-catalytic subunit of AMP-activated protein kinase (AMPK),an energy sensor protein kinase that plays a key role in regµLating cellµLar energy metabolism.In response to reduction of intracellµLar ATP levels,AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein,carbohydrate and lipid biosynthesis,as well as cell growth and proliferation.AMPK acts via direct phosphorylation of metabolic enzymes,and by longer-term effects via phosphorylation of transcription regµLators.Also acts as a regµLator of cellµLar polarity by remodeling the actin cytoskeleton;probably by indirectly activating myosin.Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles,via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1,PRKAG2 or PRKAG3). Clonality:Monoclonal Isotype:IgG Purification Method:Affinity purified Conjµgate:Non-conjµgated Buffer:Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PRKAB1 Research Areas:Cancer?CardiovascµLar;Metabolism;Signal transduction