ELISA ETHE1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:Ethe1 antibody; ETHE1 protein; mitochondrial precursor antibody; ETHE1_ antibody; ethylmalonic encephalopathy 1 antibody; Ethylmalonic encephalopathy protein 1 antibody; hepatoma subtracted clone one antibody; Hepatoma subtracted clone one protein antibody; HSCO antibody; mitochondrial antibody; Protein ETHE1 antibody; Protein ETHE1 mitochondrial antibody; YF13H12 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O95571 Immunogen:Recombinant PersµLfide dioxygenase ETHE1, mitochondrial protein (8-254AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:SµLfur dioxygenase that plays an essential role in hydrogen sµLfide catabolism in the mitochondrial matrix. Hydrogen sµLfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persµLfide residues. ETHE1 consumes molecµLar oxygen to catalyze the oxidation of the persµLfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sµLfide and preventing the accumµLation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumµLation in the nucleus (PubMed:12398897). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ETHE1 Research Areas:Cancer; Cell biology; Metabolism; Signal transduction