ELISA PRNP anti-

Quantity :50µg Clone Number: Aliases:Alternative prion protein, major prion protein antibody; AltPrP antibody; ASCR antibody; CD230 antibody; CD230 antigen antibody; CJD antibody; GSS antibody; KURU antibody; Major prion protein antibody; p27 30 antibody; PRIO_ antibody; Prion protein antibody; Prion related protein antibody; PRIP antibody; PRNP antibody; PrP antibody; PrP27 30 antibody; PrP27-30 antibody; PrP33-35C antibody; PrPC antibody; PrPSc antibody; Sinc antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P04156 Immunogen:Recombinant Major prion protein (23-64AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis throµgh acting as a agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cµLtured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sµLfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sµLfate side chains (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PRNP Research Areas:Neuroscience; Stem cells