ELISA PSEN1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:AD3 antibody; Ad3h antibody; FAD antibody; Homo Sapiens Clone CC44 Senilin 1 antibody; Presenilin-1 CTF12 antibody; Protein S182 antibody; PS 1 antibody; PS-1 antibody; PS1-CTF12 antibody; PSEN1 antibody; PSN1_ antibody; PSNL1 antibody; S182 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P49768 Immunogen:Recombinant Presenilin-1 protein (4-218AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellµLar signaling and gene expression or in linking chromatin to the nuclear membrane. StimµLates cell-cell adhesion thoµgh its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regµLating Wnt signaling. May also play a role in hematopoiesis. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PSEN1 Research Areas:Neuroscience; Cancer; Metabolism; Signal transduction