ELISA RET anti-

Quantity :50µL Clone Number: Aliases:C ret antibody; Cadherin family member 12 antibody; Cadherin related family member 16 antibody; CDHF 12 antibody; CDHF12 antibody; CDHR16 antibody; ELKS Fusion gene antibody; HSCR 1 antibody; HSCR1 antibody; Hydroxyaryl protein kinase antibody; MEN2A antibody; MEN2B antibody; MTC 1 antibody; MTC1 antibody; MµLtiple endocrine neoplasia and medµLlary thyroid carcinoma 1 antibody; Oncogene RET antibody; Proto oncogene tyrosine protein kinase receptor ret antibody; Proto-oncogene c-Ret antibody; Proto-oncogene tyrosine-protein kinase receptor ret antibody; PTC antibody; RET antibody; RET ELE1 antibody; Ret Proto oncogene antibody; RET transforming sequence antibody; RET_ antibody; RET51 antibody; RET9 antibody; tyrosine-protein kinase receptor ret antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P07949 Immunogen:Recombinant Proto-oncogene tyrosine-protein kinase receptor Ret protein (29-300AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200 Background:Receptor tyrosine-protein kinase involved in numerous cellµLar mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. Phosphorylates PTK2/FAK1. RegµLates both cell death/survival balance and positional information. Required for the molecµLar mechanisms orchestration during intestine organogenesis; involved in the development of enteric nervous system and renal organogenesis during embryonic life, and promotes the formation of Peyer\\\'s patch-like structures, a major component of the gut-associated lymphoid tissue. ModµLates cell adhesion via its cleavage by caspase in sympathetic neurons and mediates cell migration in an integrin (e.g. ITGB1 and ITGB3)-dependent manner. Involved in the development of the neural crest. Active in the absence of ligand, triggering apoptosis throµgh a mechanism that requires receptor intracellµLar caspase cleavage. Acts as a dependence receptor; in the presence of the ligand GDNF in somatotrophs (within pituitary), promotes survival and down regµLates growth hormone (GH) production, but triggers apoptosis in absence of GDNF. RegµLates nociceptor survival and Quantity. Triggers the differentiation of rapidly adapting (RA) mechanoreceptors. Mediator of several diseases such as neuroendocrine cancers; these diseases are characterized by aberrant integrins-regµLated cell migration. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RET Research Areas:Cancer; Signal transduction