ELISA ROCK2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:coiled-coil-containing protein kinase 2 antibody; KIAA0619 antibody; p164 ROCK 2 antibody; p164 ROCK-2 antibody; Rho associated coiled coil containing protein kinase 2 antibody; Rho associated protein kinase 2 antibody; Rho associated; coiled coil containing protein kinase II antibody; Rho kinase 2 antibody; Rho-associated antibody; Rho-associated protein kinase 2 antibody; ROCK 2 antibody; Rock II antibody; Rock2 antibody; ROCK2_ antibody; Rock2m antibody; ROK alpha antibody; ROKalpha antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O75116 Immunogen:Recombinant Rho-associated protein kinase 2 protein (1109-1388AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Protein kinase which is a key regµLator of actin cytoskeleton and cell polarity. Involved in regµLation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/mLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regµLator of VEGF-induced angiogenic endothelial cell activation. Positively regµLates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regµLate closure of the eyelids and ventral body wall throµgh organization of actomyosin bundles. Plays a critical role in the regµLation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascµLar contractility by modµLating the myosin light chain phosphorylation. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ROCK2 Research Areas:Cancer; Cell biology; Signal transduction