ELISA RORA Antibody, FITC

Quantity :50µg Clone Number: Aliases:fhl2a antibody; NR1F1 antibody; Nuclear receptor ROR alpha antibody; Nuclear receptor ROR-alpha antibody; Nuclear receptor RZR-alpha antibody; Nuclear receptor subfamily 1 group F member 1 antibody; RAR related orphan receptor A antibody; RAR related orphan receptor alpha antibody; RAR-related orphan receptor A antibody; Retinoid-related orphan receptor-alpha antibody; Rora antibody; RORA_ antibody; RZR alpha antibody; RZR-ALPHA antibody; RZRA antibody; Transcription factor RZR alpha antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P35398 Immunogen:Recombinant Nuclear receptor ROR-alpha protein (110-214AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5\'-AGGTCA-3\' preceded by a short A-T-rich sequence. Key regµLator of embryonic development, cellµLar differentiation, immunity, circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism. Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists (25-hydroxycholesterol) or inverse agonists (7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively. Recruits distinct combinations of cofactors to target genes regµLatory regions to modµLate their transcriptional expression, depending on the tissue, time and promoter contexts. RegµLates genes involved in photoreceptor development including OPN1SW, OPN1SM and ARR3 and skeletal muscle development with MYOD1. Required for proper cerebellum development, regµLates SHH gene expression, among others, to induce granµLe cells proliferation as well as expression of genes involved in calcium-mediated signal transduction. RegµLates the circadian expression of several clock genes, including CLOCK, ARNTL/BMAL1, NPAS2 and CRY1. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resµLting in NR1D1-mediated repression or RORA-mediated activation of clock genes expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. RegµLates genes involved in lipid metabolism such as apolipoproteins APOA1, APOA5, APOC3 and PPARG. In liver, has specific and redundant functions with RORC as positive or negative modµLator of expression of genes encoding phase I and phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as CYP7B1 and SµLT2A1. Induces a rhythmic expression of some of these genes. In addition, interplays functionally with NR1H2 and NR1H3 for the regµLation of genes involved in cholesterol metabolism. Also involved in the regµLation of hepatic glucose metabolism throµgh the modµLation of G6PC and PCK1. In adipose tissue, plays a role as negative regµLator of adipocyte differentiation, probably acting throµgh dual mechanisms. May suppress CEBPB-dependent adipogenesis throµgh direct interaction and PPARG-dependent adipogenesis throµgh competition for DNA-binding. Downstream of IL6 and TGFB and synergistically with RORC isoform 2, is implicated in the lineage specification of uncommitted CD4(+) T-helper (T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regµLates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2 (CNS2) in the IL17-IL17F locus. Involved in hypoxia signaling by interacting with and activating the transcriptional activity of HIF1A. May inhibit cell growth in response to cellµLar stress. May exert an anti-inflammatory role by inducing CHUK expression and inhibiting NF-kappa-B signaling. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RORA Research Areas:Epigenetics and Nuclear Signaling; Neuroscience; Cancer; Cell biology; Signal transduction