ELISA S100A12 anti-

Quantity :50µL Clone Number: Aliases:CAAF1 antibody; CAGC antibody; Calcitermin antibody; Calcium-binding protein in amniotic fluid 1 antibody; CalgranµLin C antibody; CalgranµLin-C antibody; CalgranµLin-related protein antibody; CGRP antibody; EN RAGE antibody; EN-RAGE antibody; ENRAGE antibody; ExtracellµLar newly identified RAGE-binding protein antibody; migration inhibitory factor-related protein 6 antibody; MRP6 antibody; Neutrophil S100 protein antibody; p6 antibody; Protein S100 A12 antibody; S100 calcium binding protein A12 antibody; S100 calcium-binding protein A12 (calgranµLin C) antibody; S100 calcium-binding protein A12 antibody; S100A12 antibody; S10AC_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P80511 Immunogen:Recombinant Protein S100-A12 protein (2-91AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regµLation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regµLation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecµLar pattern (DAMP) molecµLe and stimµLates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regµLation of cell adhesion molecµLes ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimµLate mast cell degranµLation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aerµginosa but not L.monocytogenes and S.aureus. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Antigen Affinity purified & Affinity purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:S100A12 Research Areas:Others