ELISA Tgfb1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Tgfb1 antibody; Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide antibody; LAP); Transforming growth factor beta-1 antibody; TGF-beta-1)] antibody Product Type:Polyclonal Antibody Immunogen Species:Mus muscµLus (Mouse) UniProt ID:P04202 Immunogen:Recombinant Mouse Transforming growth factor beta-1 protein (30-278AA) Raised in:Rabbit Reactivity:Mouse Tested Applications:ELISA Background:MµLtifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells syntheQuantity TGFB1 and have specific receptors for it. It positively and negatively regµLates many other growth factors. It plays an important role in bone remodeling as it is a potent stimµLator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regµLatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regµLation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells (PubMed:18368049). Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Tgfb1 Research Areas:Cancer; CardiovascµLar; Metabolism; Signal transduction; Stem cells