ELISA RRAGA Antibody, HRP

Quantity :50µg Clone Number: Aliases:Adenovirus E3 14.7 kDa-interacting protein 1 antibody; FIP-1 antibody; Rag A antibody; RagA antibody; Ras-related GTP-binding protein A antibody; RRAGA antibody; RRAGA_ antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q7L523 Immunogen:Recombinant Ras-related GTP-binding protein A protein (1-247AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Guanine nucleotide-binding protein that plays a crucial role in the cellµLar response to amino acid availability throµgh regµLation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellµLar target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RRAGA Research Areas:Epigenetics and Nuclear Signaling; Cancer; Metabolism; Microbiology; Signal transduction