ELISA RFWD3 anti-

Quantity :100µL Clone Number: Aliases:BC027246 antibody; E3 ubiquitin protein ligase RFWD3 antibody; E3 ubiquitin-protein ligase RFWD3 antibody; FLJ10520 antibody; MGC27888 antibody; RFWD3 antibody; RFWD3_ antibody; Ring finger and WD repeat domain 3 antibody; RING finger and WD repeat domain containing protein 3 antibody; RING finger and WD repeat domain-containing protein 3 antibody; RING finger protein 201 antibody; RNF201 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q6PCD5 Immunogen:SyntheQuantityd peptide derived from internal of RFWD3. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:3000 Background:E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regµLator of p53/TP53 stability, thereby regµLating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair. The MGC Project Team, Genome Res. 14:2121-2127(2004). Ota T., Nat. Genet. 36:40-45(2004). Matsuoka S., Science 316:1160-1166(2007). Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RFWD3 Research Areas:Others