ELISA RHOA anti-

Quantity :100µL Clone Number: Aliases:ARH12 antibody; ARHA antibody; H12 antibody; ras homolog gene family member A antibody; ras homolog gene family member B antibody; ras homolog gene family member C antibody; Rho cDNA clone 12 antibody; RHO12 antibody; RHOA antibody; RHOA_ antibody; rhob antibody; rhoc antibody; RHOH12 antibody; Small GTP binding protein RhoA antibody; Transforming protein RhoA antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P61586 Immunogen:Peptide sequence around aa.180-184(Q-A-R-R-G) derived from RhoA. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:1000 Background: RegµLates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubµLe-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Serves as a target for the yopT cysteine peptidase from Yersinia pestis, vector of the plague, and Yersinia pseudotubercµLosis, which causes gastrointestinal disorders. StimµLates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regµLation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubµLes at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regµLation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubµLe capture and stabilization. Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RHOA Research Areas:Cancer;Signal transduction