ELISA REST anti-

Quantity :100µL Clone Number: Aliases:Neural Restrictive Silencer Factor antibody; Neural-restrictive silencer factor antibody; Neuron Restrictive Silencer Factor antibody; NRSF antibody; RE1 silencing transcription factor antibody; RE1-silencing transcription factor antibody; Repressor binding to the X2 box antibody; rest antibody; REST protein antibody; REST_ antibody; X2 box repressor antibody; XBR antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13127 Immunogen:Peptide sequence around aa.873~877(R-E-E-A-S) derived from REST. Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regµLated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Chong J.A.et.al. (1995)Cell 80:949-957 Schoenherr C.J.et.al.(1995)Science 267:1360-1363 Scholl T.et.al.(1996)J. Immunol. 156:1448-1457 Lunyak V.V.et.al. (2002)Science 298:1747-1752 Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:REST Research Areas:Epigenetics and Nuclear Signaling?Neuroscience