ELISA RPL13A Antibody, HRP

Quantity :50µg Clone Number: Aliases:RPL13A antibody; 60S ribosomal protein L13a antibody; 23 kDa highly basic protein antibody; Large ribosomal subunit protein µL13 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P40429 Immunogen:Recombinant 60S ribosomal protein L13a protein (63-190AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3\'-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses their translation. In the GAIT complex interacts with m7G cap-bound eIF4G at or near the eIF3-binding site and blocks the recruitment of the 43S ribosomal complex. Involved in methylation of rRNA. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RPL13A Research Areas:Epigenetics and Nuclear Signaling