ELISA RPA2 (Ab-21) anti-

Quantity :100µL Clone Number: Aliases:60S acidic ribosomal protein P1 antibody; AA409079 antibody; AI325195 antibody; AU020965 antibody; ik:tdsubc_2g1 antibody; M(2)21C antibody; MGC137236 antibody; OTTHUMP00000004008 antibody; p32 antibody; p34 antibody; RCJMB04_6d17 replication protein A2; 32kDa antibody; REPA2 antibody; Replication factor A protein 2 antibody; Replication protein A 32 kDa subunit antibody; Replication protein A 32kDa subunit antibody; Replication protein A 34 kDa subunit antibody; Replication protein A antibody; Replication Protein A2 (32kDa) antibody; Replication protein A2 antibody; Replication protein A2; 32kDa antibody; RF-A protein 2 antibody; Rf-A2 antibody; RFA antibody; RFA2_ antibody; RP-A p32 antibody; RP-A p34 antibody; RP21C antibody; RPA 2 antibody; RPA 32 antibody; RPA antibody; Rpa2 antibody; RPA32 antibody; RPA34 antibody; RpLP1 antibody; RpP2 antibody; xx:tdsubc_2g1 antibody; zgc:109822 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P15927 Immunogen:SyntheQuantityd non-phosphopeptide derived from RFA2 around the phosphorylation site of threonine 21 (G-Y-T(p)-Q-S). Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; WB:1:500-1:3000, IHC:1:50-1:100 Background:As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellµLar response to DNA damage. In the cellµLar response to DNA damage the RPA complex controls DNA repair and DNA damage checkpoint activation. It is required for the recruitment of the DNA double-strand break repair factors RAD52 and RAD51 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably throµgh interaction with UNG. Throµgh RFWD3 may activate CHEK1 and play a role in replication checkpoint control. Also recruits SMARCAL1/HARP which is involved in replication fork restart to sites of DNA damage. May also play a role in telomere maintenance. Erdile L.F., J. Biol. Chem. 265:3177-3182(1990). Gregory S.G., Nature 441:315-321(2006). Niu H., J. Biol. Chem. 272:12634-12641(1997). Cho J.M., Nucleic Acids Res. 28:3478-3485(2000) Clonality:Polyclonal Isotype:IgG Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. Conjµgate:Non-conjµgated Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RPA2 Research Areas:Epigenetics and Nuclear Signaling