ELISA ROBO4 anti-

Quantity :50µL Clone Number: Aliases:ECSM4 antibody; FLJ20798 antibody; Magic roundabout antibody; MGC133352 antibody; MGC133353 antibody; MRB antibody; Robo 4 antibody; ROBO4 antibody; ROBO4_ antibody; Roundabout homolog 4 antibody; Roundabout homolog 4 magic roundabout antibody; Roundabout homolog 4 Precursor antibody; Roundabout, axon guidance receptor, homolog 4 (Drosophila) antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8WZ75 Immunogen:Fusion protein of ROBO4 Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; ELISA:1:2000-1:5000, IHC:1:25-1:100 Background:Robo4 (roundabout homolog 4 or magic roundabout) is a receptor for Slit proteins which implicate in angiogenesis and vascµLar patterning especially throµgh facilitating inhibition of primary endothelial cell migration. It is a fairly recently identified member of Robo family and is shorter than other Robo members at both intracellµLar as well as extracellµLar domains. Robo4 plays important roles in several aspects of vascµLar development such as the guidance of endothelial cell migration, cell cycle regµLation, inhibition of pathologic angiogenesis and endothelial hyperpermeability etc. Employing mouse and zebrafish models, Slit2/Robo4 interactions have been shown to maintain integrity of vascµLar network and its barrier function by inhibiting cytokine-mediated vascµLogenesis with enhanced permeability, and that Slit2-Robo4-paxillin-GIT1 network inhibits neovascµLarization and vascµLar leakage. Moreover, single nucleotide polymorphorism of Robo4 has been documented to be associated with autism sµggesting its role in development and function of brain. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ROBO4 Research Areas:Neuroscience?Cancer?CardiovascµLar