ELISA RPS6KA5 (Ab-376) anti-

Quantity :100µL Clone Number: Aliases:90 kDa ribosomal protein S6 kinase 5 antibody; EC 2.7.11.1 antibody; KS6A5_ antibody; MGC1911 antibody; Mitogen and stress activated protein kinase 1 antibody; MSPK1 antibody; Nuclear Mitogen And Stress Activated Protein Kinase 1 antibody; Nuclear mitogen- and stress-activated protein kinase 1 antibody; Ribosomal protein S6 kinase 90kD polypeptide 5 antibody; Ribosomal protein S6 kinase 90kDa antibody; Ribosomal protein S6 kinase 90kDa polypeptide 5 antibody; Ribosomal Protein S6 Kinase Alpha 5 antibody; Ribosomal protein S6 kinase alpha-5 antibody; RLPK antibody; RPS6KA5 antibody; RSK Like Protein Kinase antibody; RSK-like protein kinase antibody; RSKL antibody; S6K alpha 5 antibody; S6K-alpha-5 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O75582 Immunogen:Peptide sequence around aa.374~378 (G-Y-S-F-V) derived from MSK1. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Serine/threonine kinase required for the mitogen or stress-induced phosphorylation of the transcription factors CREB (cAMP response element-binding protein) and ATF1 (activating transcription factor-1). Essential role in the control of RELA transcriptional activity in response to TNF. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimµLi and epidemal growth-factor (EGF), which resµLts in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 14 (HMG-14). Roux PP, et al. (2004) Microbiol Mol Biol Rev. Jun; 68(2): 320-344 McCOY C, et al. (2005) Biochem J. Apr 15; 387(Pt 2): 507-517 Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RPS6KA5 Research Areas:Epigenetics and Nuclear Signaling;Cell biology;Metabolism;Signal transduction