ELISA PRKCG anti-

Quantity :50µg Clone Number: Aliases:KPCG_ antibody; MGC57564 antibody; OTTHUMP00000067291 antibody; PKC-gamma antibody; PKCC antibody; PKCG antibody; PRKCG antibody; Protein kinase C gamma antibody; Protein kinase C gamma polypeptide antibody; Protein kinase C gamma type antibody; Protein kinase C; gamma antibody; SCA 14 antibody; SCA14 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:P05129 Immunogen:Recombinant Protein kinase C gamma type protein (1-314AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IF; Recommended dilution: IF:1:50-1:200 Background:Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regµLation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modµLation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regµLates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regµLation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modµLate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drµg on the GABA(A) receptors. During and after cerebral ischemia modµLate neurotransmission and cell survival in synaptic membranes, and is involved in insµLin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of mµLtiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resµLting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which coµLd provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resµLting in phase resetting of the cerebral cortex clock (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PRKCG Research Areas:Neuroscience; Signal transduction