ELISA RING1 anti-

Quantity :100µL Clone Number: Aliases:Ring1A antibody; E3 ubiquitin-protein ligase RING1 antibody; Polycomb complex protein RING1 antibody; Really interesting new gene 1 protein antibody; RING finger protein 1 antibody; Ring1 antibody; RING1_ antibody; RING1A antibody; Rnf1 antibody; Transcription repressor Ring1A antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q06587 Immunogen:Peptide sequence around aa.35~39( I-A-V-S-P) derived from Ring1A. Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB; WB:1:500-1:1000 Background:Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regµLation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of the Polycomb group (PcG) mµLtiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throµghout development. PcG PRC1 complex act via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modµLator of RNF2/RING2 activity. Cao R., Tsukada Y., Zhang Y.Mol. Cell 20:845-854(2005) Satijn D.P.E., Gunster M.J., van der Vlag J., Hamer K.M. Mol. Cell. Biol. 17:4105-4113(1997) Clonality:Polyclonal Isotype:IgG Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjµgates. Antibodies were purified by affinity-chromatography using epitope-specific peptide. Conjµgate:Non-conjµgated Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. Form:liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RING1 Research Areas:Epigenetics and Nuclear Signaling