ELISA RNF144B anti-

Quantity :50µL Clone Number: Aliases:bA528A10.3 antibody; E3 ubiquitin protein ligase RNF144B antibody; E3 ubiquitin-protein ligase RNF144B antibody; IBR domain containing 2 antibody; IBR domain containing protein 2 antibody; IBR domain-containing protein 2 antibody; IBRDC 2 antibody; IBRDC2 antibody; KIAA0161 antibody; MGC71786 antibody; OTTHUMP00000016079 antibody; OTTHUMP00000016080 antibody; OTTHUMP00000039360 antibody; p53 inducible RING finger protein antibody; p53-inducible RING finger protein antibody; p53RFP antibody; PIR2 antibody; R144B_ antibody; Ring finger 144B antibody; RING finger protein 144B antibody; RNF 144B antibody; RNF144B antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q7Z419 Immunogen:Fusion protein of RNF144B Raised in:Rabbit Reactivity:, Mouse Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:5000, WB:1:200-1:1000, IHC:1:50-1:200 Background:p53 is the most commonly mutated gene in cancer identified to date. Expression of p53 leads to inhibition of cell growth by preventing progression of cells from G1 to S phase of the cell cycle. Most importantly, p53 functions to cause arrest of cells in the G1 phase of the cell cycle following any exposure of cells to DNA-damaging agents. The MDM2 (murine double minute-2) protein was initially identified as an oncogene in a murine transformation system. MDM2 functions to bind p53 and block p53-mediated transactivation of cotransfected reporter constructs. The MDM2 gene is amplified in a high percentage of sarcomas that retain wildtype p53 and tumor cells that overexpress MDM2 can tolerate high levels of p53 expression. Another p53 target protein is the p53-inducible RING finger protein (p53RFP), an auto-ubiquitinylated protein acting as an E3 ubiquitin ligase. p53RFP, also designated IBRDC2 in mouse and rat, receives ubiquitin from specific E2 ubiquitin-conjµgating enzymes and transfers it to substrates that promote their degradation by the proteasome. p53RFP may mediate re-entry into the cell cycle. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RNF144B Research Areas:Cell biology