ELISA PRA1 Antibody, HRP

Quantity :50µL Clone Number: Aliases:PRA1 antibody; FBP1 antibody; CAALFM_C406980WA antibody; CaO19.10623 antibody; CaO19.3111 antibody; pH-regµLated antigen PRA1 antibody; 58 kDa fibrinogen-binding mannoprotein antibody Product Type:Polyclonal Antibody Immunogen Species:Candida albicans UniProt ID:P87020 Immunogen:Recombinant Candida albicans pH-regµLated antigen PRA1 protein (16-299AA) Raised in:Rabbit Reactivity:Candida albicans Tested Applications:ELISA Background:Cell surface protein involved in the host-parasite interaction during candidal infection. With MP65, represents a major component of the biofilm matrix. Sequesters zinc from host tissue and mediates leukocyte adhesion and migration. As a surface protein, binds the two complement regµLators CFH and CFHR1, as well as plasminogen PLG, mediates complement evasion and extra-cellµLar matrix interaction and/or degradation. As a released protein, enhances complement control in direct vicinity of the yeast and thus generates an additional protective layer which controls host complement attack, assisting the fungus in escaping host surveillance. Binds to host fluid-phase C3 and blocks cleavage of C3 to C3a and C3b, leading to inhibition of complement activation. Mediates also complement control and complement evasion throµgh binding to C4BPA, another complement inhibitor, as well as throµgh binding to host integrin alpha-M/beta-2. Decreases complement-mediated adhesion, as well as uptake of C.albicans by macrophages. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PRA1 Research Areas:N/A