ELISA ROCK1 Antibody, Biotin

Quantity :50µL Clone Number: Aliases:coiled-coil-containing protein kinase 1 antibody; coiled-coil-containing protein kinase I antibody; MGC131603 antibody; MGC43611 antibody; p160 Rhoassociated coiled coil-forming protein kinase antibody; p160 ROCK-1 antibody; p160 ROCK1 antibody; p160ROCK antibody; PRO0435 antibody; Renal carcinoma antigen NY REN 35 antibody; Renal carcinoma antigen NY-REN-35 antibody; Rho associated coiled coil containing protein kinase 1 antibody; Rho associated protein kinase 1 antibody; Rho kinase antibody; Rho-alpha kinase antibody; Rho-associated antibody; Rho-associated protein kinase 1 antibody; ROCK I antibody; ROCK-I antibody; ROCK1 antibody; ROCK1_ antibody; Rok antibody; rokalpha antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13464 Immunogen:Recombinant Rho-associated protein kinase 1 protein (405-668AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Protein kinase which is a key regµLator of actin cytoskeleton and cell polarity. Involved in regµLation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/mLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regµLates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regµLating PTEN phosphorylation and stability. Acts as a negative regµLator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regµLate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction throµgh the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ROCK1 Research Areas:Cancer; Cell biology; Signal transduction