ELISA RIPK1 Antibody, HRP

Quantity :50µg Clone Number: Aliases:Cell death protein RIP antibody; FLJ39204 antibody; OTTHUMP00000039163 antibody; Receptor (TNFRSF) interacting serine threonine kinase 1 antibody; receptor interacting protein 1 antibody; Receptor interacting protein antibody; Receptor interacting protein kinase 1 antibody; Receptor interacting serine threonine protein kinase 1 antibody; Receptor TNFRSF interacting serine threonine kinase 1 antibody; Receptor-interacting protein 1 antibody; Receptor-interacting serine/threonine-protein kinase 1 antibody; Rinp antibody; RIP 1 antibody; RIP antibody; Rip-1 antibody; RIP1 antibody; RIPK 1 antibody; Ripk1 antibody; RIPK1_ antibody; Serine threonine protein kinase RIP antibody; Serine/threonine-protein kinase RIP antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q13546 Immunogen:Recombinant Receptor-interacting serine/threonine-protein kinase 1 protein (328-458AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at \'Ser-728\' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via \'Lys-63\'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecµLes. Polyubiquitinated protein binds to IKBKG/NEMO, the regµLatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellµLar RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particµLar, forms a necrosis-inducing complex. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RIPK1 Research Areas:Cancer; Cell biology; Signal transduction