ELISA RPS6KA1 Antibody, FITC

Quantity :50µg Clone Number: Aliases:90 kDa ribosomal protein S6 kinase 1 antibody; dJ590P13.1 (ribosomal protein S6 kinase; 90kD; polypeptide 1 antibody; dJ590P13.1 antibody; EC 2.7.11.1 antibody; HU 1 antibody; HU1 antibody; KS6A1_ antibody; MAP kinase activated protein kinase 1a antibody; MAP kinase-activated protein kinase 1a antibody; MAPK-activated protein kinase 1a antibody; MAPKAP kinase 1a antibody; MAPKAPK-1a antibody; MAPKAPK1A antibody; MGC79981 antibody; Mitogen-activated protein kinase-activated protein kinase 1A antibody; OTTHUMP00000004113 antibody; p90 RSK1 antibody; p90-RSK 1 antibody; p90rsk antibody; p90RSK1 antibody; p90S6K antibody; pp90RSK1 antibody; Ribosomal protein S6 kinase 90kD 1 antibody; Ribosomal protein S6 kinase 90kD polypeptide 1 antibody; Ribosomal protein S6 kinase 90kDa polypeptide 1 antibody; Ribosomal protein S6 kinase alpha 1 antibody; Ribosomal protein S6 kinase alpha-1 antibody; Ribosomal protein S6 kinase polypeptide 1 antibody; Ribosomal S6 kinase 1 antibody; RPS6K1 alpha antibody; rps6ka antibody; Rps6ka1 antibody; RSK 1 antibody; RSK 1 p90 antibody; RSK antibody; RSK-1 antibody; RSK1 antibody; RSK1p90 antibody; S6K alpha 1 antibody; S6K-alpha-1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q15418 Immunogen:Recombinant Ribosomal protein S6 kinase alpha-1 protein (233-400AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regµLates translation throµgh RPS6 and EIF4B phosphorylation, and mediates cellµLar proliferation, survival, and differentiation by modµLating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimµLated phosphorylation of CREB1, which resµLts in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimµLation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insµLin-derived signal, acts indirectly on the transcription regµLation of several genes by phosphorylating GSK3B at \'Ser-9\' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the pre-initiation complex. In response to insµLin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimµLating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at \'Ser-1798\', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regµLates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Mediates induction of hepatocyte prolifration by TGFA throµgh phosphorylation of CEBPB (By similarity). Is involved in cell cycle regµLation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RPS6KA1 Research Areas:Epigenetics and Nuclear Signaling; Signal transduction