ELISA RSPO1 anti-

Quantity :50µL Clone Number: Aliases:CRISTIN3, FLJ40906, hRspo1, R spondin homolog, R spondin homolog (Xenopus laevis), R spondin1, R-spondin-1, Roof plate specific spondin, Roof plate-specific spondin-1, RP11-566C13.1, RSPO, Rspo1, RSPO1_ Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q2MKA7 Immunogen:Recombinant R-spondin-1 protein (21-263AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200 Background:Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellµLar Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regµLates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regµLator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regµLate the TGF-beta pathway. Has a essential roles in ovary determination. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen Affinity Purified Conjµgate:Non-conjµgated Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3. Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RSPO1 Research Areas:Developmental biology; Stem cells