ELISA Ripk1 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:Ripk1 antibody; Rinp antibody; Rip antibody; Receptor-interacting serine/threonine-protein kinase 1 antibody; EC 2.7.11.1 antibody; Cell death protein RIP antibody; Receptor-interacting protein 1 antibody; RIP-1 antibody Product Type:Polyclonal Antibody Immunogen Species:Mus muscµLus (Mouse) UniProt ID:Q60855 Immunogen:Recombinant Mouse Receptor-interacting serine/threonine-protein kinase 1 protein (1-656AA) Raised in:Rabbit Reactivity:Mouse Tested Applications:ELISA Background:Serine-threonine kinase which transduces inflammatory and cell-death signals (programmed necrosis) following death receptors ligation, activation of pathogen recognition receptors (PRRs), and DNA damage. Upon activation of TNFR1 by the TNF-alpha family cytokines, TRADD and TRAF2 are recruited to the receptor. Phosphorylates DAB2IP at \'Ser-728\' in a TNF-alpha-dependent manner, and thereby activates the MAP3K5-JNK apoptotic cascade. Ubiquitination by TRAF2 via \'Lys-63\'-link chains acts as a critical enhancer of communication with downstream signal transducers in the mitogen-activated protein kinase pathway and the NF-kappa-B pathway, which in turn mediate downstream events including the activation of genes encoding inflammatory molecµLes. Polyubiquitinated protein binds to IKBKG/NEMO, the regµLatory subunit of the IKK complex, a critical event for NF-kappa-B activation. Interaction with other cellµLar RHIM-containing adapters initiates gene activation and cell death. RIPK1 and RIPK3 association, in particµLar, forms a necrosis-inducing complex (By similarity). Interacts with ARHGEF2 (By similarity). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:Ripk1 Research Areas:Cancer; Cell biology; Signal transduction