ELISA SGMS1 anti-

Quantity :50µg Clone Number: Aliases:SGMS1 antibody; MOB antibody; SMS1 antibody; TMEM23 antibody; Phosphatidylcholine:ceramide cholinephosphotransferase 1 antibody; EC 2.7.8.27 antibody; MedµLla oblongata-derived protein antibody; Protein Mob antibody; Sphingomyelin synthase 1 antibody; Transmembrane protein 23 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q86VZ5 Immunogen:Recombinant Phosphatidylcholine:ceramide cholinephosphotransferase 1 protein (48-137AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500 Background:Sphingomyelin synthases syntheQuantity the sphingolipid, sphingomyelin, throµgh transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Golgi apparatus SMS1 directly and specifically recognizes the choline head group on the substrate, requiring two fatty chains on the choline-P donor molecµLe in order to be recognized efficiently as a substrate. Major form in macrophages. Required for cell growth in certain cell types such as HeLa cells. Suppresses BAX-mediated apoptosis and also prevents cell death in response to stimµLi such as hydrogen peroxide, osmotic stress, elevated temperature and exogenously supplied sphingolipids. May protect against cell death by reversing the stress-inducible increase in levels of proapoptotic ceramide. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:SGMS1 Research Areas:Cancer; Metabolism; Signal transduction