ELISA RFX6 Antibody, HRP

Quantity :50µg Clone Number: Aliases:RFX6 antibody; RFXDC1 antibody; DNA-binding protein RFX6 antibody; RegµLatory factor X 6 antibody; RegµLatory factor X domain-containing protein 1 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q8HWS3 Immunogen:Recombinant DNA-binding protein RFX6 protein (1-260AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insµLin (PubMed:20148032, PubMed:25497100). Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regµLates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032). Involved in glucose-stimµLated insµLin secretion by promoting insµLin and L-type calcium channel gene transcription (PubMed:25497100). Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:HRP Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RFX6 Research Areas:Others