ELISA PRIMPOL anti-

Quantity :50µg Clone Number: Aliases:CC111_ antibody; CCDC111 antibody; Coiled coil domain containing 111 antibody; Coiled-coil domain-containing protein 111 antibody; DNA-directed primase/polymerase protein antibody; MYP22 antibody; Primase and polymerase (DNA directed) antibody; PRIMPOL antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q96LW4 Immunogen:Recombinant DNA-directed primase/polymerase protein (305-537AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200 Background:DNA primase and DNA polymerase able to initiate de novo DNA synthesis using dNTPs. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA. Involved in translesion synthesis via its primase activity by mediating uninterrupted fork progression after programmed or damage-induced fork arrest and by reinitiating DNA synthesis after dNTP depletion. Required for mitochondrial DNA (mtDNA) synthesis, sµggesting it may be involved in DNA tolerance during the replication of mitochondrial DNA. Has non-overlapping function with POLH. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Non-conjµgated Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:PRIMPOL Research Areas:Epigenetics and Nuclear Signaling