ELISA RNF2 Antibody, Biotin

Quantity :50µg Clone Number: Aliases:BAP 1 antibody; BAP1 antibody; DING antibody; DinG protein antibody; E3 ubiquitin protein ligase RING 2 antibody; E3 ubiquitin protein ligase RING2 antibody; E3 ubiquitin-protein ligase RING2 antibody; HIP2 interacting protein 3 antibody; HIP2-interacting protein 3 antibody; HIPI 3 antibody; HIPI3 antibody; Huntingtin interacting protein 2 interacting protein 3 antibody; Huntingtin-interacting protein 2-interacting protein 3 antibody; OTTHUMP00000060668 antibody; Polycomb M33 interacting protein Ring 1B antibody; Polycomb M33 interacting protein Ring1B antibody; Protein DinG antibody; RING 1B antibody; RING 2 antibody; RING finger protein 1B antibody; RING finger protein 2 antibody; RING finger protein BAP 1 antibody; RING finger protein BAP-1 antibody; RING finger protein BAP1 antibody; RING1b antibody; RING2_ antibody; RNF 2 antibody; Rnf2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q99496 Immunogen:Recombinant E3 ubiquitin-protein ligase RING2 protein (158-290AA) Raised in:Rabbit Reactivity: Tested Applications:ELISA Background:E3 ubiquitin-protein ligase that mediates monoubiquitination of \'Lys-119\' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regµLation. H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation. Essential component of a Polycomb group (PcG) mµLtiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throµghout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4. Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modµLator of RNF2/RING2 activity. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:Biotin Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RNF2 Research Areas:Epigenetics and Nuclear Signaling