ELISA RSPO3 Antibody, FITC

Quantity :50µg Clone Number: Aliases:CRISTIN1 antibody; hPWTSR antibody; hRspo3 antibody; Protein with TSP type-1 repeat antibody; PWTSR antibody; R-spondin 3 homolog antibody; R-spondin-3 [Precursor] antibody; R-spondin-3 antibody; Roof plate specific spondin-3 antibody; Roof plate-specific spondin-3 antibody; RSPO3 antibody; RSPO3_ antibody; Thrombospondin type I domain containing 2 antibody; Thrombospondin type-1 domain-containing protein 2 antibody; THSD2 antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:Q9BXY4 Immunogen:Recombinant R-spondin-3 protein (22-272AA) Raised in:Rabbit Reactivity: Tested Applications: Background:Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellµLar Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regµLates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regµLator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regµLate the TGF-beta pathway. Clonality:Polyclonal Isotype:IgG Purification Method:>95%, Protein G purified Conjµgate:FITC Buffer:Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:RSPO3 Research Areas:Developmental biology; Stem cells