ELISA Recombinant Staphylococcus aureus Chemotaxis inhibitory protein(chp)
>Several Other Quantitys Are Also Available. Please Inquire. DefaµLt Quantity: 200µg
Updated Date: Stock Protein updated on 20170405
Research areas: others
Target / Protein: chp
Biologically active: Not Tested
Expression system: Yeast
Species of origin: Staphylococcus aureus (strain MRSA252)
Delivery time: 3-7 business days
Uniprot ID: Q6GFB3
AA Sequence: FTFEPFPTNEEIESNKKmLEKEKAYKESFKNSGLPTTLGKLDERLRNYLKKGTKNSAQFEKMVILTENKGYYTVYLNTPLAEDRKNVELLGKMYKTYFFKKGESKSSYVINGPGKTNEYAY
Tag info: N-terminal 6xHis-tagged
Expression Region: 29-149aa
Protein length: FµLl length of mature protein
MW: 16.1 kDa
Alternative Name(s): CHIPS
Relevance: Involved in countering the first line of host defense mechanisms. Specifically inhibits the response of neutrophils and monocytes to complement anaphylatoxin C5a and formylated peptides, like N-formyl-methionyl-leucyl-phenylalanine (fmLP). Acts by binding directly to the C5a receptor (C5aR) and formylated peptide receptor (FPR), thereby blocking the C5a- and fmLP-induced calcium responses. Prevents phagocytosis of the bacterium
Reference: "Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virµLence and drµg resistance." Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J., Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A., Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C., Clark L., Corton C. Parkhill J.Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004)
Purity: Greater than 90% as determined by SDS-PAGE.
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
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