ELISA PRKAR1A anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.) Background:cAMP is a signaling molecµLe important for a variety of cellµLar functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal throµgh phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regµLatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regµLatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regµLatory subunits and three catalytic subunits have been identified in s. This gene encodes one of the regµLatory subunits. This protein was found to be a tissue-specific extinguisher that down-regµLates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which sµggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. Immunogen:protein kinase, cAMP-dependent, regµLatory, type I, alpha (tissue specific extinguisher 1) Synonyms:PKR1, PRKAR1, TSE1 Observed MW:45 kDa Uniprot ID:P10644 Reactivity: Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:500 - 1:2000; IHC: 1:50 - 1:200 Gene ID:5573 Research Area:Signal Transduction, Metabolism