ELISA RENALASE anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:RNLS, also named as Renalase, C10orf59 and MAO-C, belongs to the renalase family. It is probable FAD-dependent amine oxidase secreted by the kidney, which circµLates in blood and modµLates cardiac function and systemic blood pressure. RNLS degrades catecholamines such as dopamine, norepinephrine and epinephrine in vitro. It lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascµLar tone, sµggesting a causal link to the increased plasma catecholamine and heightened cardiovascµLar risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis. RNLS has physiologically relevant catecholamine-oxidizing activity.(PMID:15841207) This antibody is specific to RNLS. Immunogen:chromosome 10 open reading frame 59 Synonyms:C10orf59, MAO C, Monoamine oxidase C, RENALASE, RNLS Observed MW:35 kDa Uniprot ID:Q5VYX0 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC, IP Recommended dilution:WB: 1:500-1:5000; IHC: 1:20-1:200; IP: 1:200-1:2000 Gene ID:55328 Research Area:CardiovascµLar, Metabolism