ELISA REST anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Transcriptional repressor which binds neuron-restrictive silencer element(NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regµLated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression. Immunogen:RE1-silencing transcription factor Synonyms:NRSF, REST, X2 box repressor, XBR Observed MW:122 kDa, 200kd Uniprot ID:Q13127 Reactivity:, Rat Tested Application:ELISA, WB, IP Recommended dilution:WB: 1:500-1:1000; IP: 1:500-1:2000 Gene ID:5978 Research Area:Stem Cells, Metabolism