ELISA RFFL anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:E3 ubiquitin-protein ligase that regµLates several biological processes throµgh the ubiquitin-mediated proteasomal degradation of various target proteins. Mediates 'Lys-48'-linked polyubiquitination of PRR5L and its subsequent proteasomal degradation thereby indirectly regµLating cell migration throµgh the mTORC2 complex. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regµLate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis. Negatively regµLates the tumor necrosis factor-mediated signaling pathway throµgh targeting of RIPK1 to ubiquitin-mediated proteasomal degradation. Negatively regµLates p53/TP53 throµgh its direct ubiquitination and targeting to proteasomal degradation. Indirectly, may also negatively regµLate p53/TP53 throµgh ubiquitination and degradation of SFN. May also play a role in endocytic recycling. Immunogen:ring finger and FYVE-like domain containing 1 Synonyms:RNF189, RNF34L Observed MW:37-41 kDa Uniprot ID:Q8WZ73 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:117584 Research Area:Epigenetics, Metabolism