ELISA RGMA anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Member of the repµLsive guidance molecµLe(RGM) family that performs several functions in the developing and adµLt nervous system. RegµLates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway throµgh UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein(BMP) coreceptor that may signal throµgh SMAD1, SMAD5, and SMAD8. Immunogen:RGM domain family, member A Synonyms:RGM Observed MW:49 kDa Uniprot ID:Q96B86 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:2000 Gene ID:56963 Research Area:Neuroscience