ELISA RGS14 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:RegµLates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Besides, modµLates signal transduction via G protein alpha subunits by functioning as a GDP-dissociation inhibitor(GDI). Has GDI activity on G(i) alpha subunits GNAI1 and GNAI3, but not on GNAI2 and G(o) alpha subunit GNAO1. Has GAP activity on GNAI0, GNAI2 and GNAI3. May act as a scaffold integrating G protein and Ras/Raf MAPkinase signaling pathways. Inhibits platelet-derived growth factor(PDGF)-stimµLated ERK1/ERK2 phosphorylation; a process depending on its interaction with HRAS and that is reversed by G(i) alpha subunit GNAI1. Acts as a positive modµLator of microtubµLe polymerisation and spindle organization throµgh a G(i)-alpha-dependent mechanism. Plays a role in cell division. Required for the nerve growth factor(NGF)-mediated neurite outgrowth. Involved in stress resistance. May be involved in visual memory processing capacity and hippocampal-based learning and memory. Immunogen:regµLator of G-protein signaling 14 Synonyms: Observed MW:60-65 kDa Uniprot ID:O43566 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:2000 Gene ID:10636 Research Area:Signal Transduction