ELISA RICTOR anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Subunit of mTORC2, which regµLates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regµLate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for fµLl activation. mTORC2 regµLates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modµLates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. Immunogen:rapamycin-insensitive companion of mTOR Synonyms:AVO3 homolog, hAVO3, KIAA1999, mAVO3, RICTOR Observed MW:192 kDa Uniprot ID:Q6R327 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC Recommended dilution:WB: 1:1000-1:5000; IHC: 1:50-1:200 Gene ID:253260 Research Area:Developmental biology