ELISA RNF4 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:E3 ubiquitin-protein ligase which binds polysumoylated chains covalently attached to proteins and mediates 'Lys-6'-, 'Lys-11'-, 'Lys-48'-and 'Lys-63'-linked polyubiquitination of those substrates and their subsequent targeting to the proteasome for degradation. RegµLates the degradation of several proteins including PmL and the transcriptional activator PEA3. Involved in chromosome alignment and spindle assembly, it regµLates the kinetochore CENPH-CENPI-CENPK complex by targeting polysumoylated CENPI to proteasomal degradation. RegµLates the cellµLar responses to hypoxia and heat shock throµgh degradation of respectively EPAS1 and PARP1. Alternatively, it may also bind DNA/nucleosomes and have a more direct role in the regµLation of transcription for instance enhancing basal transcription and steroid receptor-mediated transcriptional activation. Immunogen:ring finger protein 4 Synonyms:SNURF Observed MW: Uniprot ID:P78317 Reactivity:, Mouse, Rat Tested Application:ELISA, IP Recommended dilution:IP: 1:200-1:2000 Gene ID:6047 Research Area:Cancer, Metabolism, Developmental biology