ELISA RNF41 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Acts as E3 ubiquitin-protein ligase and regµLates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regµLates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicµLar stomatitis virus(By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin(EPO) and interleukin-3(IL-3) receptors. Thus, throµgh maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages(By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regµLator of cell death by promoting apoptosis. Acts also as a PARK2 modifier that accelerates its degradation, resµLting in a reduction of PARK2 activity, influencing the balance of intracellµLar redox state. The RNF41-PARK2 pathway regµLates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control(PubMed:24949970). Immunogen:ring finger protein 41 Synonyms:FLRF, NRDP1 Observed MW:36 kDa Uniprot ID:Q9H4P4 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:500-1:2000 Gene ID:10193 Research Area:Epigenetics, Metabolism