ELISA ROCK2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Protein kinase which is a key regµLator of actin cytoskeleton and cell polarity. Involved in regµLation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/mLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regµLator of VEGF-induced angiogenic endothelial cell activation. Positively regµLates the activation of p42/MAPK1-p44/MAPK3 and of p90RSK/RPS6KA1 during myogenic differentiation. Plays an important role in the timely initiation of centrosome duplication. Inhibits keratinocyte terminal differentiation. May regµLate closure of the eyelids and ventral body wall throµgh organization of actomyosin bundles. Plays a critical role in the regµLation of spine and synaptic properties in the hippocampus. Plays an important role in generating the circadian rhythm of the aortic myofilament Ca(2+) sensitivity and vascµLar contractility by modµLating the myosin light chain phosphorylation. Immunogen:Rho-associated, coiled-coil containing protein kinase 2 Synonyms:KIAA0619 Observed MW:161 kDa Uniprot ID:O75116 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC, IF, IP Recommended dilution:WB: 1:1000-1:10000; IP: 1:200-1:2000;; IHC: 1:20-1:200; IF: 1:10-1:100 Gene ID:9475 Research Area:Signal Transduction, Metabolism, CardiovascµLar, Cancer, Developmental biology, Cell Division and Proliferation