ELISA RORB anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Nuclear receptor that binds DNA as a monomer to ROR response elements(RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid(ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. ModµLates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regµLates transcription of OPN1SW. Involved in the regµLation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regµLate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation throµgh the inhibition of RUNX2 transcriptional activity(By similarity). Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. RegµLates the expression of PTF1A synergistically with FOXN4(By similarity). Immunogen:RAR-related orphan receptor B Synonyms:NR1F2, RZRB Observed MW:52 kDa Uniprot ID:Q92753 Reactivity:, Mouse, Rat Tested Application:ELISA, WB, IHC, IP Recommended dilution:WB: 1:500-1:2000; IP: 1:200-1:1000; IHC: 1:20-1:200 Gene ID:6096 Research Area:Neuroscience, Signal Transduction, Metabolism, Developmental biology