ELISA RORC anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Nuclear receptor that binds DNA as a monomer to ROR response elements(RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Key regµLator of cellµLar differentiation, immunity, peripheral circadian rhythm as well as lipid, steroid, xenobiotics and glucose metabolism(PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Considered to have intrinsic transcriptional activity, have some natural ligands like oxysterols that act as agonists(25-hydroxycholesterol) or inverse agonists(7-oxygenated sterols), enhancing or repressing the transcriptional activity, respectively(PubMed:19965867, PubMed:22789990). Recruits distinct combinations of cofactors to target gene regµLatory regions to modµLate their transcriptional expression, depending on the tissue, time and promoter contexts. RegµLates the circadian expression of clock genes such as CRY1, ARNTL/BMAL1 and NR1D1 in peripheral tissues and in a tissue-selective manner. Competes with NR1D1 for binding to their shared DNA response element on some clock genes such as ARNTL/BMAL1, CRY1 and NR1D1 itself, resµLting in NR1D1-mediated repression or RORC-mediated activation of the expression, leading to the circadian pattern of clock genes expression. Therefore influences the period length and stability of the clock. Involved in the regµLation of the rhythmic expression of genes involved in glucose and lipid metabolism, including PLIN2 and AVPR1A(PubMed:19965867). Negative regµLator of adipocyte differentiation throµgh the regµLation of early phase genes expression, such as MMP3. Controls adipogenesis as well as adipocyte Quantity and modµLates insµLin sensitivity in obesity. In liver, has specific and redundant functions with RORA as positive or negative modµLator of expression of genes encoding phase I and Phase II proteins involved in the metabolism of lipids, steroids and xenobiotics, such as SµLT1E1. Also plays also a role in the regµLation of hepatocyte glucose metabolism throµgh the regµLation of G6PC and PCK1(PubMed:19965867). RegµLates the rhythmic expression of PROX1 and promotes its nuclear localization(PubMed:19381306, PubMed:19965867, PubMed:22789990, PubMed:26160376, PubMed:20203100). Plays an indispensable role in the induction of IFN-gamma dependent anti-mycobacterial systemic immunity(PubMed:26160376). Isoform 2: Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes and Peyer's patches. Required for the generation of LTi(lymphoid tissue inducer) cells. RegµLates thymocyte survival throµgh DNA-binding on ROREs of target gene promoter regions and recruitment of coactivaros via the AF-2. Also plays a key role, downstream of IL6 and TGFB and synergistically with RORA, for lineage specification of uncommitted CD4(+) T-helper(T(H)) cells into T(H)17 cells, antagonizing the T(H)1 program. Probably regµLates IL17 and IL17F expression on T(H) by binding to the essential enhancer conserved non-coding sequence 2(CNS2) in the IL17-IL17F locus. May also play a role in the pre-TCR activation cascade leading to the maturation of alpha/beta T-cells and may participate in the regµLation of DNA accessibility in the TCR-J(alpha) locus. Immunogen:RAR-related orphan receptor C Synonyms:NR1F3, Nuclear receptor ROR gamma, Nuclear receptor RZR gamma, RAR related orphan receptor C, RORC, RORG, RZR GAMMA, RZRG, TOR Observed MW:58 kDa Uniprot ID:P51449 Reactivity:, Mouse, Rat Tested Application:ELISA, WB Recommended dilution:WB: 1:500 - 1:2000 Gene ID:6097 Research Area:Neuroscience, Signal Transduction, Metabolism, Developmental biology