ELISA RSAD2 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:Interferon-inducible iron-sµLfur(4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including cytomegalovirus(HCMV), hepatitis C virus(HCV), west Nile virus(WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicµLar stomatitis virus(VSV), and immunodeficiency virus(HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, throµgh binding and inhibition of the enzyme farnesyl diphospate synthase(FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells(pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor(TCR)-mediated GATA3 activation and optimal T-helper 2(Th2) cytokine production by modµLating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins. Immunogen:radical S-adenosyl methionine domain containing 2 Synonyms:2510004L01Rik, cig33, cig5, RSAD2, vig1, Viperin Observed MW:45 kDa Uniprot ID:Q8WXG1 Reactivity:, Mouse Tested Application:ELISA, WB, IF, IHC Recommended dilution:WB: 1:500-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100 Gene ID:91543 Research Area:Immunology, Metabolism