ELISA RUNX1 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, LCK, IL-3 and GM-CSF promoters. The alpha subunit binds DNA and appears to have a role in the development of normal hematopoiesis. Isoform AmL-1L interferes with the transactivation activity of RUNX1. Acts synergistically with ELF4 to transactivate the IL-3 promoter and with ELF2 to transactivate the mouse BLK promoter. Inhibits KAT6B-dependent transcriptional activation. Controls the anergy and suppressive function of regµLatory T-cells(Treg) by associating with FOXP3. Activates the expression of IL2 and IFNG and down-regµLates the expression of TNFRSF18, IL2RA and CTLA4, in conventional T-cells(PubMed:17377532). Immunogen:runt-related transcription factor 1 Synonyms:AmL1, CBFA2 Observed MW:48-55 kDa Uniprot ID:Q01196 Reactivity:, Mouse Tested Application:ELISA, WB, IF Recommended dilution:WB: 1:500-1:2000; IF: 1:20-1:200 Gene ID:861 Research Area:Stem Cells, cancer, Neuroscience, Developmental biology