ELISA SOCS3 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:SOCS family proteins form part of a classical negative feedback system that regµLates cytokine signal transduction. SOCS3 is involved in negative regµLation of cytokines that signal throµgh the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insµLin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. Suppresses fetal liver erythropoiesis. RegµLates onset and maintenance of allergic responses mediated by T-helper type 2 cells. RegµLates IL-6 signaling in vivo(By similarity). Probable substrate recognition component of a SCF-like ECS(Elongin BC-CµL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST(By similarity). Immunogen:suppressor of cytokine signaling 3 Synonyms:ATOD4, CIS 3, CIS3, Cish3, SOCS 3, SOCS3, SSI 3, SSI3, STAT induced STAT inhibitor 3 Observed MW:30 kDa Uniprot ID:O14543 Reactivity:, Mouse, Rat Tested Application:ELISA, IHC, WB, IF, IP Recommended dilution:WB: 1:200-1:2000; IP: 1:200-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100 Gene ID:9021 Research Area:Signal Transduction, Developmental biology