ELISA RNF34 anti-

Quantity:100µg Purification:Immunogen affinity purified Form:liquid Purity:?95% as determined by SDS-PAGE Host:Rabbit Clonality:polyclonal Clone ID: Isotype:IgG Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.) Background:E3 ubiquitin-protein ligase that regµLates several biological processes throµgh the ubiquitin-mediated proteasomal degradation of various target proteins. Ubiquitinates the caspases CASP8 and CASP10, promoting their proteasomal degradation, to negatively regµLate cell death downstream of death domain receptors in the extrinsic pathway of apoptosis(PubMed:15069192). May mediate 'Lys-48'-linked polyubiquitination of RIPK1 and its subsequent proteasomal degradation thereby indirectly regµLating the tumor necrosis factor-mediated signaling pathway(Ref.13). Negatively regµLates p53/TP53 throµgh its direct ubiquitination and targeting to proteasomal degradation(PubMed:17121812). Indirectly, may also negatively regµLate p53/TP53 throµgh ubiquitination and degradation of SFN(PubMed:18382127). Mediates PPARGC1A proteasomal degradation probably throµgh ubiquitination thereby indirectly regµLating the metabolism of brown fat cells(PubMed:22064484). Possibly involved in innate immunity, throµgh 'Lys-48'-linked polyubiquitination of NOD1 and its subsequent proteasomal degradation(PubMed:25012219). Immunogen:ring finger protein 34 Synonyms:CARP 1, Caspase regµLator CARP1, FYVE RING finger protein Momo, hRFI, RFI, RIF, RIFF, ring finger protein 34, RING finger protein RIFF, RNF34 Observed MW:41 kDa Uniprot ID:Q969K3 Reactivity: Tested Application:WB Recommended dilution:WB: 1:200-1:2000 Gene ID:80196 Research Area:Cell Division and Proliferation